Tysabri (natalizumab) was reported in a small retrospective study to significantly improve cognitive abilities in people with relapsing-remitting MS patients (RRMS) over two years of use.
The study, “Improvement in Cognitive Function as Measured by NeuroTrax in Patients with Relapsing Multiple Sclerosis Treated with Natalizumab: A 2-Year Retrospective Analysis,” was published in the journal CNS Drugs.
About 40-65% of MS patients have cognitive impairment, one of the disease’s most disabling symptoms. It strongly affects patients’ quality of life, in both their personal and professional areas, and can impact their employment prospects.
NeuroTrax is a validated computerized screening test of cognition that provides a global score based on seven domains — executive function, memory, attention, visual-spatial processing, information processing speed, verbal function, and motor function.
A large-scale study using NeuroTrax showed that MS patients have poorer cognitive abilities than healthy people, particularly in areas involving information processing speed and executive function — and such problems worsen with disease duration. The test is rarely used, however, to assess treatment response in MS patients.
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