Ocrevus in Advanced Progressive Multiple Sclerosis (pertaining to younger and elder patients with MS)

a video by : Dr. Brandon Beaber

Does ocrevus work in people with progressive MS with more significant disability?

The OROTORIO-HAND trial addresses this topic.

Lets review the preliminary data which has not yet been published. Selected Sources Ocrevus product label: https://www.accessdata.fda.gov/drugsa…

AAN 2026: Ocrevus treatment slows disability in advanced PPMS: https://multiplesclerosisnewstoday.co…

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O’HAND): https://clinicaltrials.gov/study/NCT0…
ORATORIO-HAND: Results of the Primary Analysis of Ocrelizumab vs Placebo in Primary Progressive Multiple Sclerosis, In: https://www.aan.com/msa/Public/Events…

Older Patients and Those With More Advanced Disease Roche presents new data for OCREVUS and fenebrutinib across broad patient populations at ECTRIMS 2025: https://www.roche.com/media/releases/… Ocrelizumab Demonstrates Efficacy Over Placebo in Phase 3b ORATORIO-HAND Trial of Primary Progressive MS: https://www.neurologylive.com/view/oc…

Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial: https://pubmed.ncbi.nlm.nih.gov/19847…