Oct 22, 2011
New data from a late-stage trial showed that 78 percent of patients treated with Lemtrada remained relapse-free for two years, compared with 59 percent using Rebif, an older multiple sclerosis drug sold by Germany’s Merck.
New data from a late-stage trial showed that 78 percent of patients treated with Lemtrada remained relapse-free for two years, compared with 59 percent using Rebif, an older multiple sclerosis drug sold by Germany’s Merck.
Lemtrada is a key experimental product at Sanofi’s Genzyme unit. The fortunes of the drug are closely watched by holders of Genzyme Contingent Value Rights certificates issued to shareholders as part of the U.S. company’s takeover deal.
CVRs represent an extra fee holders will receive if Lemtrada hits certain targets or when Genzyme meets other milestones.
The commercial potential of the drug, already sold under the brand name Campath as a leukemia treatment, was a key bone of contention between Sanofi and Genzyme during takeover talks.
Multiple sclerosis, which affects 2.5 million people worldwide, is a chronic and progressive disease that attacks the central nervous system.
Previously published data from the same late-stage study were mixed. Although Lemtrada was found more effective than Rebif at preventing relapses, it did not prevent the disease from becoming disabling, as it had in earlier trials.
The results of the latest late-stage trial showed that side-effects, including respiratory and urinary tract infections, were mild to moderate, Sanofi said.
Serious adverse events were similar between Lemtrada and Rebif, Sanofi said, with 18.4 percent of patients on Lemtrada suffering from side effects that included autoimmune disorders compared to 14.4 percent in patients taking Rebif.
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