Understanding MS spinal lesions

Stuart SchlossmanMultiple Sclerosis

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People can exhibit many symptoms of MS, but a definitive diagnosis cannot be achieved with the naked eye.
The most effective and non-invasive way to determine if a person has MS is to scan for brain and spinal cord lesions using magnetic resonance imaging (MRI).
Lesions are usually the most telling symptom of an MS diagnosis. According to the National MS Society, only about 5 percent of people with MS do not show lesions on MRI at the time of diagnosis.
MRI uses strong magnetic and radio waves to produce detailed pictures of the brain and spinal cord. This scan can effectively show any scarring or damage to the myelin sheath associated with MS.

Demyelination, or the progressive stripping of the myelin sheath in the CNS, is a staple of MS. Since myelin coats the nerve fibers that travel through both the brain and the spinal cord, demyelination creates lesions in both areas.
This means that if someone with MS has brain lesions, they are also likely to have spinal lesions as well.
Spinal cord lesions are common in MS. They’re found in about 80 percent of people newly diagnosed with MS.
Sometimes the number of spinal lesions identified from an MRI can provide the doctor with an idea of the severity of the MS and the likelihood of a more serious episode of demyelination occurring in the future. However, the exact science behind the number of lesions and their location is still not entirely understood.
It’s not known why some people with MS may have more lesions in their brain than their spinal cord, or vice versa. However, it should be noted that spinal lesions do not necessarily indicate a diagnosis of MS, and can sometimes lead to a misdiagnosis of MS.

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