New findings uncover the mechanisms by which gut bacteria can trigger inflammation in the brain and contribute to multiple sclerosis
Suhayl Dhib-Jalbut,
M.D., to present findings in keynote address at ACTRIMS Forum 2018
M.D., to present findings in keynote address at ACTRIMS Forum 2018
Madison, Wis., Nov. 30,
2017 – A breakthrough in the understanding of how altered gut bacteria
breaks immune tolerance towards the brain, and how this can trigger the immune
system to attack brain tissue, will be presented as the subject of the keynote Kenneth
P. Johnson Memorial Lecture on the opening day of the Americas Committee for
Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2018.
2017 – A breakthrough in the understanding of how altered gut bacteria
breaks immune tolerance towards the brain, and how this can trigger the immune
system to attack brain tissue, will be presented as the subject of the keynote Kenneth
P. Johnson Memorial Lecture on the opening day of the Americas Committee for
Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2018.
ACTRIMS
Forum 2018 will take place Feb. 1-3, in San Diego, California, U.S.
An altered gut microbiota, known as dysbiosis, is often
observed in patients with multiple sclerosis (MS), but it has not been clear
how this contributes to the onset or progression of the disease. New research,
conducted by Suhayl Dhib-Jalbut, M.D., Sudhir Yadav, Ph.D. and Kouichi Ito, Ph.D.,
all investigators at the Rutgers-Robert Wood Johnson Center for Multiple
Sclerosis, provides evidence that dysbiosis stimulates the development of
pathogenic T cells in mice, thereby initiating or exacerbating an animal model
of MS.
observed in patients with multiple sclerosis (MS), but it has not been clear
how this contributes to the onset or progression of the disease. New research,
conducted by Suhayl Dhib-Jalbut, M.D., Sudhir Yadav, Ph.D. and Kouichi Ito, Ph.D.,
all investigators at the Rutgers-Robert Wood Johnson Center for Multiple
Sclerosis, provides evidence that dysbiosis stimulates the development of
pathogenic T cells in mice, thereby initiating or exacerbating an animal model
of MS.
This discovery has potential therapeutic implications in MS
by manipulating the composition of gut bacteria, according to study researcher Dhib-Jalbut,
who will present the findings of the team’s research.
Furthermore, “the findings could have potential implications
on other autoimmune diseases above and beyond MS,” says Dhib-Jalbut.
on other autoimmune diseases above and beyond MS,” says Dhib-Jalbut.
The late Kenneth P. Johnson, M.D., University of Maryland,
led the effort to found ACTRIMS in 1996. The Memorial Lecture honors Johnson by
providing an opportunity for ACTRIMS audiences to hear from prestigious
clinicians or researchers selected for their knowledge, accomplishments and
contributions related to MS.
led the effort to found ACTRIMS in 1996. The Memorial Lecture honors Johnson by
providing an opportunity for ACTRIMS audiences to hear from prestigious
clinicians or researchers selected for their knowledge, accomplishments and
contributions related to MS.
ACTRIMS Forum brings together researchers and clinicians to
share developments in the rapidly changing field of MS. More information about ACTRIMS
Forum 2018, and the Kenneth P. Johnson Memorial Lecture appears on the event’s
website at www.actrims.org/forum2018.
share developments in the rapidly changing field of MS. More information about ACTRIMS
Forum 2018, and the Kenneth P. Johnson Memorial Lecture appears on the event’s
website at www.actrims.org/forum2018.
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