University of Huddersfield Team Develops Blood Test for Diagnosing MS

University of Huddersfield researchers have developed a blood test for diagnosing multiple sclerosis that avoids the invasive, painful process of collecting fluid from the brain and spine.

The team at the British discussed the test in an article titled “Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS.” It appeared in the journal Analytical Methods.

Medical technicians check the blood sample for two biomarkers of MS — sphingosine and dihydrosphingosine. Scientists have discovered that levels of the compounds are significantly lower in MS patients’ blood.

In addition to offering a new diagnostic tool, the discovery may help scientists learn more about the compounds’ role in the disease, potentially leading to therapies.

“Sphingosine and dihydrosphingosine have been previously found to be at lower concentrations in the brain tissue of patients with multiple sclerosis,” the researchers wrote said in a news release. “The detection of these sphingolipids in blood plasma allows the non-invasive monitoring of these and related compounds.”

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