Undetected disease activity may increase MS patients’ risk of disability

In MS, clinical and subclinical disease activity can occur
early in the disease course and persist throughout the disease.^1-3

•	Emerging scientific research shows that a considerable amount of disease activity may elude detection⁴ See research about lesion detection >
•	Even small amounts of subclinical or clinical disease activity can be predictive of future disability, and can result in permanent damage^2,5 Review the impact of disease activity on disability >

Shining a Light on Multiple Sclerosis.

References:

1.	Polman CH, Reingold SC, Banwell, B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011(2);69:292-302.
2.	Scott TF, Hackett CT, Quigley MR, Schramke CJ. Relapsing multiple sclerosis patients treated with disease modifying therapy exhibit highly variable disease progression: a predictive model. Clin Neurol. 2014(127);86-92.
3.	Prosperini L, Gallo V, Petsas N, Borriello G, Pozzilli C. One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis. Eur J Neurol. 2009;16(11):1202-1209.
4.	de Graaf WL, Kilsdonk ID, Lopez-Soriano A, et al. Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter. Eur Radiol. 2013;23(2):528-540.
5.	Rio J, Nos C, Tintoré M, et al. Assessment of different treatment failure criteria in a cohort of relapsing–remitting multiple sclerosis patients treated with interferon β: implications for clinical trials. Ann Neurol. 2002;52(4):400-406.

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