Adrenocorticotropic hormone (ACTH), or corticotropin, is a hormone that is produced in and released from the pituitary gland. ACTH is normally released from the pituitary in response to stimulation with corticotropin-releasing hormone (CRH), a hormone produced in the hypothalamic region of the brain during various types of stress or pain. The principal action of ACTH is to stimulate the synthesis and release of steroid hormones from the adrenal glands, which lie on the surface of the kidneys. ACTH is the principal modulator of cortisol, the most important steroid hormone in man.
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