Vaccine Effectiveness and MS

People taking certain DMTs (ocrelizumab, rituximab, ofatumumab, and possibly fingolimod, siponimod, ozanimod, ponesimod and others) will have a reduced and possibly undetectable antibody response to the COVID-19 vaccines. If you use one of these DMTs and take an antibody test following your vaccine, it may show a decreased or undetectable antibody level. Even if your antibodies are undetectable or low, you could be protected from COVID-19 since other components of the immune system are triggered by the vaccine and could contribute to your protection.

Even though the current COVID-19 vaccines are highly effective, some people can still become infected with COVID-19 and give it to others. While research on the immune response to the vaccines in MS (described above) is underway, the safest approach is to ensure those closest to you are vaccinated. When in settings where you are unsure of the vaccination status of those around you, continue to wear a mask, practice physical distancing, wash your hands frequently and follow local rules about getting tested for COVID-19 when necessary.