Undetected disease activity may increase MS patients’ risk of disability

Stuart SchlossmanMS Research Study and Reports, Multiple Sclerosis, Multiple Sclerosis (MS) Symptoms

In MS, clinical and subclinical disease activity can occur
early in the disease course and persist throughout the disease.1-3
•
Emerging scientific research shows that a considerable
amount of disease activity may elude detection4
See research about lesion detection >
•
Even small amounts of subclinical or clinical disease
activity can be predictive of future disability, and can result in
permanent damage2,5
Review the impact of disease activity on
disability >
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Shining a Light on Multiple Sclerosis.
References:
1.
Polman CH, Reingold SC, Banwell, B, et al. Diagnostic
criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol.
2011(2);69:292-302.
2.
Scott TF, Hackett CT, Quigley MR, Schramke CJ. Relapsing
multiple sclerosis patients treated with disease modifying therapy exhibit
highly variable disease progression: a predictive model. Clin Neurol.
2014(127);86-92.
3.
Prosperini L, Gallo V, Petsas N, Borriello G, Pozzilli C.
One-year MRI scan predicts clinical response to interferon beta in multiple
sclerosis. Eur J
Neurol. 2009;16(11):1202-1209.
4.
de Graaf WL, Kilsdonk ID, Lopez-Soriano A, et al. Clinical
application of multi-contrast 7-T MR imaging in multiple sclerosis:
increased lesion detection compared to 3 T confined to grey matter. Eur Radiol.
2013;23(2):528-540.
5.
Rio J, Nos C, Tintoré M, et al. Assessment of different
treatment failure criteria in a cohort of relapsing–remitting multiple
sclerosis patients treated with interferon β: implications for clinical
trials. Ann Neurol.
2002;52(4):400-406.






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