July 2021
Sativex (nabiximols), an oral spray that contains cannabis extracts, was found effective as an add-on therapy for easing spasticity in adult multiple sclerosis (MS) patients who failed to respond to other anti-spastic treatments, a real-world study from Belgium reports.
Overall, about 74% patients reported easing of spasticity — muscle stiffness or spasms —after 12 weeks of treatment, defined as a 30%-or-greater reduction in spasticity scores.
The study, “Sativex (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience,” was published in the journal BMC Neurology.
Sativex, developed by GW Pharmaceuticals, is an oral spray that contains cannabidiol (CBD) and tetrahydrocannabinol (THC), two of the most abundant cannabinoids found in the cannabis plant.
Sprayed under the tongue or inside the cheek several times a day, Sativex is available in 25 countries — including most of Europe and Canada, but not the U.S. — as an add-on therapy for adult patients with moderate-to-severe MS spasticity who fail to respond to other anti-spastic treatments.
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