- Collaborators in Cambridge and San Francisco used advanced technology to evaluate genetic instructions within single brain cells in specific areas of brain tissues from people who had MS in their lifetimes, before there were disease-modifying therapies.
- They report that a specific type of nerve cell called “projection neurons” – which normally facilitate communication between different areas of the brain – are especially vulnerable to damage in the cortex (the outer region of the brain, associated with disease progression and cognitive impairment).
- They also confirmed the role of immune B cells in this type of damage.
- This study yields important new information about how MS may progress and why certain symptoms worsen. If confirmed, it is likely to contribute to efforts to develop better, more targeted ways to stop the disease, protect the nervous system from further injury, and slow down MS progression.
- This study was funded by the National MS Society and the National Institutes of Health, among others.
- The team published their findings in Nature (Published: 17 July 2019)
DETAILSBackground: MS occurs when the immune system attacks the brain and spinal cord. Disease progression is associated with damage in the cortex, the outer region of the brain, which is responsible for directing cognitive functions. The Study: Investigators at the University of Cambridge and the University of California, San Francisco looked at tissue obtained from 12 people with MS via autopsy (who had never received modern disease-modifying therapies) and from 9 controls without the disease. They used single-nucleus RNA sequencing, a novel technology which allowed them to isolate many types of cells in the cortex, evaluate the genetic instructions and compare different populations of cells. The researchers pinpointed a striking reduction of one cell type in the brain tissue obtained from people with MS – so called “projection neurons.” These are nerve cells involved in communicating information between distant areas of the brain. Further results showed that immune B cells were increased in areas with more damage to those projection neurons, highlighting the role of this immune cell type. This work, by Drs. David Rowitch, Lucas Schirmer and others, was funded by the National MS Society and the National Institutes of Health, among others. Dr. Schirmer was a postdoctoral fellow of the Society, funded by the Dave Tomlinson Research Fund. The team published their findings in Nature (Published: 17 July 2019)Conclusions: This study yields important new information about how MS may progress and why certain symptoms worsen. If confirmed, it is likely to contribute to efforts to develop better, more targeted ways to stop the disease, protect the nervous system from further injury, and slow down MS progression.
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