Mult Scler; ePub 2018 Mar 7; Koenig, et al
March 20, 2018
March 20, 2018
Functional activation may be useful as a predictive measure of episodic memory loss in patients with multiple sclerosis (MS), a recent study found. Researchers used functional magnetic resonance imaging (fMRI) during a verbal episodic memory task, lesion load, and volumetric measures of the hippocampus and thalamus to assess the relative contributions to verbal and visual-spatial episodic memory in persons with MS (n=32) and healthy controls (n=16). They found:
- After adjusting for disease duration, immediate recall performance on a visual-spatial episodic memory task was significantly predicted by hippocampal volume.
- Delayed recall on the same task was significantly predicted by volume of the left thalamus.
- For both memory measures, functional activation of the thalamus during encoding was more predictive than that of volume measures.
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