Omid Mirmosayyeb 1, Mohammad Yazdan Panah 2, Yousef Mokary 2, Elham Moases Ghaffary 2, Hamed Ghoshouni 2, Robert Zivadinov 3, Bianca Weinstock-Guttman 1, Dejan Jakimovski 4
Affiliations expand
PMID: 37924591 DOI: 10.1016/j.jns.2023.120847
Abstract
Background: Studies have demonstrated that people with multiple sclerosis (pwMS) experience visual impairments and neurodegenerative retinal processes. The disability progression in pwMS may be associated with retinal changes assessed with optical coherence tomography (OCT). This meta-analysis aims at synthesizing the correlations between OCT measurements of disability in pwMS.
Methods: We systematically searched four databases (PubMed/MEDLINE, Embase, Scopus, and Web of Science) from inception to November 2022, then conducted a meta-analysis using a random effects model to determine the pooled correlation coefficient(r) between OCT measurements and disability scales by R version 4.2.3 with the meta version 6.2-1 package.
Results: From 3129 studies, 100 studies were included. Among 9051 pwMS, the female-to-male ratio was 3.15:1, with a mean age of 39.57 ± 6.07 years. The mean disease duration and Expanded Disability Status Scale (EDSS) were 8.5 ± 3.7 and 2.7 ± 1.1, respectively. Among the pooled subgroup analyses, macular ganglion cell inner plexiform layer (mGCIPL) in patients with relapsing-remitting (pwRRMS) and peripapillary retinal nerve fiber layer (pRNFL) in patients with progressive MS (pwPMS) had strong correlations with EDSS, r = -0.33 (95% CI: -0.45 to -0.20, I2 = 45%, z-score = -4.86, p < 0.001) and r = -0.20 (95% CI:-0.58 to 0.26, I2 = 76%, z-score = -0.85, p = 0.395), respectively.
According to subgroup analysis on pwMS without optic neuritis (ON) history, the largest correlation was seen between EDSS and macular ganglion cell complex (mGCC): r = -0.39 (95% CI: -0.70 to 0.04, I2 = 79%, z-score = -1.79, p = 0.073).
Conclusion: OCT measurements are correlated with disability in pwMS, and they can complement the comprehensive neurological visit as an additional paraclinical test.
Copyright © 2023 Elsevier B.V. All rights reserved.
Conflict of interest statement — Read here
Stay informed with MS information, news and resources. Sign-up Here: https://bit.ly/3NkMIeR
Visit the MS Views and News articles and videos archives: https://wwwmsviewsandrelatednews.blog
Visit us on Facebook: www.facebook.com/msviewsandnews
Visit us on Twitter (X): www.twitter.com/MSViewsandNews
Visit us on Instagram: www.instagram.com/msviewsandnews