Definition
Optic neuritis is a vision disorder characterized by inflammation of the optic nerve.
Description
Optic neuritis occurs when the optic nerve, the pathway that transmits visual information to the brain, becomes inflamed and the myelin sheath that surrounds the nerve is destroyed (a process known as demyelination). It typically occurs in one eye at a time (70%), and the resulting vision loss is rapid and progressive, but only temporary. Thirty percent of patients experience occurrence in both eyes. Optic neuritis tends to afflict young adults with an average age in their 30s. Seventy-five percent of patients with optic neuritis are women.
Nerve damage that occurs in the section of the optic nerve located behind the eyeball, is called retrobulbar neuritis, and is most often associated with multiple sclerosis. Optic nerve inflammation and edema (swelling) caused by intracranial pressure at the place where the nerve enters the eyeball is termedpapillitis.
Causes and symptoms
Symptoms of optic neuritis include one or more of the following:
- blurred or dimmed vision
- blind spots, particularly with central vision
- pain with eye movement
- headache
- sudden color blindness
- impaired night vision
- impaired contrast sensitivity
Optic neuritis is most commonly associated with multiple sclerosis (MS). Other causes include viral or fungal infections, encephalomyelitis, autoimmune diseases, or pressure on the nerve from tumors or vascular diseases (i.e., temporal arteritis). Some toxins, such as methanol and lead, can also damage the optic nerve, as can long-term abuse of alcohol and tobacco. Patients with non-MS related optic neuritis are usually immunocompromised in some way.
Diagnosis
An ophthalmologist, a physician trained in diseases of the eye, will typically make a diagnosis of optic neuritis. A complete visual exam, including a visual acuity test, color vision test, and examination of the retina and optic disc with an ophthalmoscope, will be performed. Clinical signs such as impaired pupil response may be apparent during an eye exam, but in some cases the eye may appear normal. A medical history will also be performed to determine if exposure to toxins such as lead may have caused the optic neuritis.
Further diagnostic testing such as magnetic resonance imaging (MRI) may be necessary to confirm a diagnosis of optic neuritis. An MRI can also reveal signs of multiple sclerosis.
Treatment
Treatment of optic neuritis depends on the underlying cause of the condition. Vision loss resulting from a viral condition usually resolves itself once the virus is treated, and optic neuritis resulting from toxin damage may improve once the source of the toxin is removed.
A course of intravenous corticosteroids (steroids) followed by oral steroids has been found to be helpful in restoring vision quickly to patients with MS-related episodes of optic neuritis, but its efficacy in preventing relapse is debatable. The Optic Neuritis Treatment Trial (ONTT) has shown that IV steroids may be effective in reducing the onset of MS for up to two years, but further studies are necessary. Oral prednisone has been found to increase the likelihood of recurrent episodes of optic neuritis, and is not recommended for treating the disorder.
Prognosis
The vision loss associated with optic neuritis is usually temporary. Spontaneous remission occurs in two to eight weeks. Sixty-five to eighty percent of patients can expect 20/30 or better vision after recovery. Long-term prognosis depends on the underlying cause of the condition. If a viral infection has triggered the episode, it frequently resolves itself with no after effects. If optic neuritis is associated with multiple sclerosis, future episodes are not uncommon. Thirty-three percent of optic neuritis cases recur within five years. Each recurrence results in less recovery and worsening vision. There is a strong association between optic neuritis and MS. In those without multiple sclerosis, half who experience an episode of vision loss related to optic neuritis will develop the disease within 15 years.
Prevention
Regular annual eye exams are critical to maintaining healthy vision. Early treatment of vision problems can prevent permanent optic nerve damage (atrophy).
Resources
Books
Leitman, Mark. Manual for Eye Examination and Diagnosis. 5th ed. Boston: Blackwell Science, 2001.
Periodicals
Cohen, Joyce Render, et al. “Living with Low Vision.” Inside MS 1 (2001): 46.
Organizations
Prevent Blindness America. 500 East Remington Road, Schaumburg, IL 60173. (800) 331-2020. http://www.prevent-blindness.org.
Source for definition: Free Dictionary
..
===========================================================
Remain CURRENT with Multiple Sclerosis news and information
Providing You with MS Views and News, is what we do
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
On the Fourth Wednesday of Each Month
Visit: StuMSradio – With Deanna and Stu
or click : Multiple Sclerosis-UnPlugged
* Call (347) 215-9265 *
To listen, speak with us or speak with a guest
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
“MS Views and News” is a 501©(3) Not-for-Profit organization as
recognized by the Internal Revenue Service.
All contributions are tax deductible to the fullest extent allowed by law.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Disclaimer: ‘MS Views and News’ (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly. .
Visit our MS Learning Channel on YouTube: http://www.youtube.com/msviewsandnews