Ofatumumab Increases NEDA-3 ( no evidence of disease activity) Likelihood in MS, Compared With Teriflunomide

Novartis’s anti-CD20 monoclonal antibody has been shown to increase the odds of patients with multiple sclerosis achieving no evidence of disease activity status by more than 3-fold in the first year and more than 8-fold in the second year.

New data from a pooled analysis of the phase 3 ASCLEPIOS I and II clinical trials suggest that patients with multiple sclerosis (MS) treated with ofatumumab have an increased likelihood of achieving no evidence of disease activity (NEDA-3) than those treated with teriflunomide (Aubagio; Sanofi).¹

Click HERE to Subscribe for the MS Beacon Newsletter

All told, the odds of achieving NEDA-3 status—defined as a composite of no 6-month confirmed disability worsening (6mCDW), no confirmed MS relapse, no new/enlarging T2 lesions, and no gadolinium-enhancing (Gd+) T1 lesions—were more than 3-fold higher for those administered ofatumumab from Months 0 to 12 (47%) compared to those taking teriflunomide (24.5%; odds ratio [OR], 3.36 [95%CI, 2.67–4.21]; P <.001). From Months 12 to 24, those odds increased to more than 8-fold higher for those on ofatumumab (87.8%) compared with teriflunomide (48.2%; OR, 8.09 [95%CI, 6.26–10.45]; P <.001).

The data were analyzed by Stephen L. Hauser, MD, director, UCSF Weill Institute for Neurosciences, and professor of neurology, UCSF School of Medicine, and colleagues, and were presented at the 2020 Annual Meeting of the Consortium of Multiple Sclerosis Centers (CMSC 2020). The analysis included data on 927 patients from ASCLEPIOS I (NCT02792218) and 955 patients from ASCLEPIOS II (NCT02792231), and investigated the effect of subcutaneous ofatumumab 20-mg monthly compared with oral teriflunomide 14-mg once daily.

Visit our MS Learning Channel on YouTube: http://www.youtube.com/msviewsandnews