Brain
volumes in children with multiple sclerosis (MS) were smaller than in those
without the disease due to a lack of age-expected brain growth and progressive
atrophy, researchers reported.
Using longitudinal MRI data from patients with relapsing-remitting MS onset
prior to age 18, Berengere Aubert-Broche, PhD, of McGill University in Montreal
and colleagues noted that “significant group and age interactions were
found with the adjusted models fitting brain volumes and normalized thalamus
volumes (P<0.10-4).” They also found that T2 lesion volume
correlated with a greater reduction in age-expected thalamic volume compared
with children without MS.
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