“Lights, Camera, Take Action on MS”

AUBAGIO® is available in 14 mg and 7 mg tablets. Trouble viewing? View as a Web page IMPORTANT SAFETY INFORMATION Do not take AUBAGIO if you have severe liver problems, are pregnant or are of childbearing age and not using effective birth control, or are taking a medication called leflunomide. VIEW MORE Please click here for full Prescribing Information, including boxed WARNING and Medication Guide

Genzyme has teamed up with TV and film actress Madeleine Stowe to launch “Lights, Camera, Take Action on MS.” This program is aimed at providing education and resources to people living with relapsing forms of multiple sclerosis and their families – so they can take action to help manage the disease. Visit TakeActionMS.com to learn more, and sign up for a live event where Madeleine will share her personal connection to the disease, and you can learn more about topics ranging from managing stress and maintaining energy to the emotional impact of MS. Go to AUBAGIO.com to learn about the impact of AUBAGIO 14 mg on relapse rates, disability progression and lesions on MRI scans. AUBAGIO® (teriflunomide) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS).

IMPORTANT SAFETY INFORMATION Do not take AUBAGIO: • If you have severe liver problems. AUBAGIO may cause serious liver problems, which can be life-threatening. Your risk may be higher if you take other medicines that affect your liver. Your healthcare provider should do blood tests to check your liver within 6 months before you start AUBAGIO and monthly for 6 months after starting AUBAGIO. Tell your healthcare provider right away if you develop any of these symptoms of liver problems: nausea, vomiting, stomach pain, loss of appetite, tiredness, yellowing of your skin or whites of your eyes, or dark urine. • If you take a medicine called leflunomide. • If you are pregnant or are of childbearing potential and not using effective birth control. AUBAGIO may harm an unborn baby. You should have a pregnancy test before starting AUBAGIO. After stopping AUBAGIO, continue to use effective birth control until you have made sure your blood levels of AUBAGIO are lowered. If you become pregnant while taking AUBAGIO or within 2 years after stopping, tell your healthcare provider right away and enroll in the AUBAGIO Pregnancy Registry at 1-800-745- 4447, option 2. It is not known if AUBAGIO passes into breast milk. Your healthcare provider can help you decide if you should take AUBAGIO or breastfeed – you should not do both at the same time. If you are a man whose partner plans to become pregnant, you should stop taking AUBAGIO and talk with your healthcare provider about reducing the levels of AUBAGIO in your blood. If your partner does not plan to become pregnant, use effective birth control while taking AUBAGIO. AUBAGIO may stay in your blood for up to 2 years after you stop taking it. Your healthcare provider can prescribe a medicine that can remove AUBAGIO from your body quickly. Before taking AUBAGIO, talk with your healthcare provider if you have: liver or kidney problems; a fever or infection, or if you are unable to fight infections; numbness or tingling in your hands or feet that is different from your MS symptoms; diabetes; serious skin problems when taking other medicines; breathing problems; or high blood pressure. Your healthcare provider will check your white blood cell count and TB test before you start AUBAGIO. Talk with your healthcare provider if you take or are planning to take other medicines (especially medicines for treating cancer or controlling your immune system), vaccines, vitamins or herbal supplements. AUBAGIO may cause serious side effects, including: reduced white blood cell count – this may cause you to have more infections; numbness or tingling in your hands or feet that is different from your MS symptoms; kidney problems; high potassium levels in your blood; serious skin problems; breathing problems (new or worsening); and high blood pressure. The most common side effects when taking AUBAGIO include: abnormal liver test results; hair thinning or loss; diarrhea; flu; upset stomach; and burning or prickling feeling in your skin. These are not all the side effects of AUBAGIO. Tell your healthcare provider about any side effect that bothers you. Consult your healthcare provider if you have questions about your health or any medications you may be taking, including AUBAGIO. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. Please click here for full Prescribing Information, including boxed WARNING and Medication Guide.

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