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April 27, 2016
Researchers at the Center of Excellence for Myelin Repair, a part of Mount Sinai, reported that gut bacteria produce compounds that were seen to affect the myelin content in mice and cause social avoidance behaviors. Study results indicated that targeting gut bacteria, or the gut metabolites, might help in treating neuropsychiatric disorders or complications, such as those caused by diseases like multiple sclerosis (MS).
The study, published in journal eLife, is titled “Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior.”
Previous studies from the same research team described a reduction of myelin and myelinated fibers in preclinical models of depression, postulating a biological explanation for the high rate of depression in patients with MS.
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