MS
Research Drug working for PPMS
Research Drug working for PPMS
Arun T,
Tomassini V, Sbardella E, de Ruiter MB, Matthews L, Leite MI, Gelineau-Morel R,
Cavey A, Vergo S, Craner M, Fugger L, Rovira A, Jenkinson M, Palace J. Targeting ASIC1 in primary
progressive multiple sclerosis: evidence of neuroprotection with amiloride. Brain.
2013;136(Pt 1):106-15.
Tomassini V, Sbardella E, de Ruiter MB, Matthews L, Leite MI, Gelineau-Morel R,
Cavey A, Vergo S, Craner M, Fugger L, Rovira A, Jenkinson M, Palace J. Targeting ASIC1 in primary
progressive multiple sclerosis: evidence of neuroprotection with amiloride. Brain.
2013;136(Pt 1):106-15.
Neurodegeneration
is the main cause for permanent disability in multiple sclerosis. The effect of
current immunomodulatory treatments on neurodegeneration is insufficient.
Therefore, direct neuroprotection and myeloprotection remain an important
therapeutic goal. Targeting acid-sensing ion channel 1 (encoded by the ASIC1
gene), which contributes to the excessive intracellular accumulation of
injurious Na(+) and Ca(2+) and is over-expressed in acute multiple sclerosis
lesions, appears to be a viable strategy to limit cellular injury that is the
substrate of neurodegeneration.
is the main cause for permanent disability in multiple sclerosis. The effect of
current immunomodulatory treatments on neurodegeneration is insufficient.
Therefore, direct neuroprotection and myeloprotection remain an important
therapeutic goal. Targeting acid-sensing ion channel 1 (encoded by the ASIC1
gene), which contributes to the excessive intracellular accumulation of
injurious Na(+) and Ca(2+) and is over-expressed in acute multiple sclerosis
lesions, appears to be a viable strategy to limit cellular injury that is the
substrate of neurodegeneration.
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