Researchers found that 22 of 23 patients with elevated CSF NfL at baseline had normal levels at 2-year follow-up.
Kimberly Allen-Philbey, PhD candidate
Data from a recent study suggest that subcutaneous cladribine personalized dosing (CPD) was well-tolerated in patients with relapsing multiple sclerosis (RMS), with efficacy in line with oral cladribine (Mavenclad; EMD Serono) trial data.
These findings were presented at the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2021, February 25-27, 2021, by Kimberley Allen-Philbey, PhD candidate, Neuroscience and Trauma, The Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London.
“Oral cladribine is a licensed disease-modifying treatment (DMT) for [RMS]. We have experience treating a large cohort with this compound, ranging from early to advanced MS, using off-label subcutaneous cladribine personalized dosing since 2014,” Allen-Philbey and colleagues wrote.
The researchers offered CPD to people with MS regardless of disease course. Treatment schedule consisted of 10 mg on 3 consecutive days in week 1 (4 days in people over 90 kg), another 0-3 doses in week 5 based on total lymphocyte count in week 4. A second cycle of CPD was administered 11 months later.
Follow-up recorded adverse events (AEs), relapses, annual Expanded Disability Status Scale (EDSS) scores, 9-Hole Peg Test scores, Timed 25-Foot Walking Test scores, and Symbol Digit Modalities Test scores. Magnetic resonance imaging (MRI) with gadolinium to enhance T1 and T2 lesions was performed, and cerebrospinal fluid (CSF) neurofilament light chain (NfL) measurements and full blood counts were obtained.