Autoimmunity Rates Are on the Rise in the United States, Study Says

Stuart SchlossmanMisc. MS Related

By Beth Levine – April 17, 2020


Certain subgroups, such as adolescents and males, are at greater risk.

photo illustration of blood test tubes rising
An increase in the presence of certain antibodies, found through a blood test, suggests that autoimmunity is becoming more common.iStock; Everyday Health
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Autoimmunity is a condition in which the body’s immune system reacts against its own healthy cells and tissues. A study conducted by scientists at the National Institutes of Health (NIH) and published online on April 7, 2020, in Arthritis and Rheumatology shows a concerning rise in the United States population of the presence of antinuclear antibodies (ANA), the most common biomarker of autoimmunity. Over the course of 25 years, the researchers found an overall 50 percent increase, but certain subgroups showed significantly higher rates than the rest of the population.

The researchers studied the population at three different periods, each approximately 10 years apart.
  • 1988 to 1991 There was an 11 percent frequency of ANA in the representative sample of the population of the United States.
  • 1999 to 2004 That rose to 11.5 percent.
  • 2011 to 2012 The rate was around 16 percent. The most dramatic increase occurred from the second to the third time period.

Biggest Autoimmunity Biomarker Increases Found in Specific Subgroups

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