Assessing and Managing Disease Progression in Relapsing Forms of Multiple Sclerosis

Stuart SchlossmanMS Research Study and Reports, Pediatric MS

 

A baseline predictor of 9-year disability worsening was the presence of optic nerve lesions; the 1-year Expanded Disability Status Scale (EDSS) change and 2-year EDSS change also predicted 9-year disability worsening.

A baseline magnetic resonance imaging (MRI) assessment and subsequent clinical and MRI monitoring during the first 2 years of multiple sclerosis (MS) onset in children can likely provide insights into patients’ 9-year prognosis, according to study results published in the Annals of Neurology.

This longitudinal, observational study included data from clinical and MRI assessments at disease onset and after 1 and 2 years from 123 children (mean age, 14.4 years) with relapsing-remitting MS. Study investigators conducted a clinical follow up in these patients at 9 years and used Cox proportional hazard and multivariable regression models to examine independent predictors of time to first relapse and outcomes at 9 years.

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