#Ampyra Significantly Improves Walking Ability As Reported by MS Patients, Phase 3 Trial Shows

Treatment with Ampyra (dalfampridine) for 24 weeks leads to sustained and clinically meaningful improvements in walking ability as reported by multiple sclerosis (MS) patients with gait difficulties, according to a study analyzing results from a Phase 3 trial.

The study, “Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine” was published in the journal CNS Drugs.

More than 90 percent of MS patients have difficulty walking, which reduces their independence and negatively affects their quality of life and productivity.

Ampyra (prolonged-release dalfampridine tablets) is an approved MS medication marketed by Acorda Therapeutics in the U.S. It is the first therapy specifically approved to help improve walking in adults with MS. A generic version of #Ampyra was made available this year in the U.S. by Mylan. In Europe, the medicine is approved under the brand name Fampyra, being marketed by Biogen.

An international group of researchers involved in the clinical trial ENHANCE — a large study evaluating Ampyra’s efficacy — conducted the present study to see whether the therapy could improve, in a clinically meaningful way, the walking ability of MS patients based on data from the trial.