Advances in Understanding of Depression Offers New Hope

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Depression is thought to affect about one in 10 Americans.1 In 2010, antidepressants were the second most commonly prescribed type of medication in the US,2 hinting at the severity of the problem.
Contrary to popular belief, depression is not likely caused by unbalanced brain chemicals; however there are a number of other biological factors that appear to be highly significant. Chronic inflammation is one. As noted in the featured article:3
“George Slavich, a clinical psychologist at the University of California in Los Angeles, has spent years studying depression, and has come to the conclusion that it has as much to do with the body as the mind.
‘I don’t even talk about it as a psychiatric condition anymore,’ he says. ‘It does involve psychology, but it also involves equal parts of biology and physical health.’
The basis of this new view is blindingly obvious once it is pointed out: everyone feels miserable when they are ill. That feeling of being too tired, bored and fed up to move off the sofa and get on with life is known among psychologists as sickness behaviour.

 It happens for a good reason, helping us avoid doing more damage or spreading an infection any further. It also looks a lot like depression.”

One researcher even goes so far as to suggest depression should be rebranded as an infectious but non-contagious disease,4 while the author of the featured article playfully compares depression with an allergic reaction—in this case “an allergy to modern life”—considering the many environmental factors that are known to cause inflammation, from diet to toxic exposures and stress.
Scientists have also found that your mental health can be adversely impacted by factors such as vitamin D deficiency and/or unbalanced gut flora—both of which, incidentally, play a role in keeping inflammation in check, which is really what the remedy to depression is all about.

Inflammation and Depression

As discussed in an article by Dr. Kelly Brogan, depressive symptoms can be viewed as downstream manifestations of inflammation.
“The source itself may be singularly or multiply-focused as stress, dietary and toxic exposures, and infection… [I]nflammation appears to be a highly relevant determinant of depressive symptoms such as flat mood, slowed thinking, avoidance, alterations in perception, and metabolic changes,5she writes.

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