A presentation at the American Society of Nephrology 44th Annual Meeting, showed study results of H.P. Acthar® Gel, a natural adrenocorticotropic hormone (ACTH) designed for treatment of acute exacerbations of multiple sclerosis in adults, and as mono-therapy for the treatment of IS in infants and children under 2 years of age. Acthar® may induce a remission of proteinuria in patients with idiopathic membranous nephropathy (iMN), a common cause of nephrotic syndrome in adults. The remission is induced by suppressing production of antibodies to the phospholipase A2 receptor (PLA2R). It has been established that Nephrotic syndrome is a risk factor for progression to end-stage renal disease (ESRD). Nephrotic syndrome is a nonspecific disorder that can be caused by numerous underlying diseases and disorders, such as iMN, primary focal segmental glomerular sclerosis (FSGS) and other conditions.
It is caused by damage of the kidney glomeruli in which tiny blood vessels filter the blood’s waste and excess water into the urine, causing large amounts of protein to leak from the blood into the urine, a condition known as proteinuria. Questcor estimates, based on epidemiology data and extensive market research with nephrologists, that about 8,000 patients in the US suffer from nephrotic syndrome caused by iMN, and a similar number due to primary FSGS but there are also several other less common causes. If not appropriately treated or if non-responsive to treatment, patients with these types of idiopathic nephrotic syndrome often progress to ESRD, which according to ASN estimations affects over 500,000 patients in the US. This figure is projected to increase by 50% over the next 20 years. ESRD can be caused by several kidney disorders, and in the U.S., each year over 100,000 new ESRD cases are diagnosed. The only therapy available for ESRD patients is dialysis and kidney transplant. Continue Reading
It is caused by damage of the kidney glomeruli in which tiny blood vessels filter the blood’s waste and excess water into the urine, causing large amounts of protein to leak from the blood into the urine, a condition known as proteinuria. Questcor estimates, based on epidemiology data and extensive market research with nephrologists, that about 8,000 patients in the US suffer from nephrotic syndrome caused by iMN, and a similar number due to primary FSGS but there are also several other less common causes. If not appropriately treated or if non-responsive to treatment, patients with these types of idiopathic nephrotic syndrome often progress to ESRD, which according to ASN estimations affects over 500,000 patients in the US. This figure is projected to increase by 50% over the next 20 years. ESRD can be caused by several kidney disorders, and in the U.S., each year over 100,000 new ESRD cases are diagnosed. The only therapy available for ESRD patients is dialysis and kidney transplant. Continue Reading
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