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With a recent request from an MS patient, we are posting this article, from Sept 2016
A temporary tattoo containing
antioxidant nanoparticles may help treat autoimmune diseases such as multiple
sclerosis in the future, according to a new study.
antioxidant nanoparticles may help treat autoimmune diseases such as multiple
sclerosis in the future, according to a new study.
The study led by Christine Beeton
from Baylor College of Medicine in the US shows that nanoparticles modified
with polyethylene glycol (PEG) are conveniently choosy as they are taken up by
cells in the immune system.
from Baylor College of Medicine in the US shows that nanoparticles modified
with polyethylene glycol (PEG) are conveniently choosy as they are taken up by
cells in the immune system.
That could be a plus for patients
with autoimmune diseases like multiple sclerosis, researchers said.”Placed
just under the skin, the carbon-based particles form a dark spot that fades
over about one week as they are slowly released into the circulation,”
Beeton said.
with autoimmune diseases like multiple sclerosis, researchers said.”Placed
just under the skin, the carbon-based particles form a dark spot that fades
over about one week as they are slowly released into the circulation,”
Beeton said.
T and B lymphocyte cells and
macrophages are key components of the immune system. However, in many
autoimmune diseases like multiple sclerosis, T cells are the key players.
macrophages are key components of the immune system. However, in many
autoimmune diseases like multiple sclerosis, T cells are the key players.
One suspected cause is that T
cells lose their ability to distinguish between invaders and healthy tissue and
attack both.In tests, nanoparticles were internalised by T cells, which
inhibited their function, but ignored by macrophages.
cells lose their ability to distinguish between invaders and healthy tissue and
attack both.In tests, nanoparticles were internalised by T cells, which
inhibited their function, but ignored by macrophages.
“The ability to selectively
inhibit one type of cell over others in the same environment may help doctors
gain more control over autoimmune diseases,” Beeton said.
inhibit one type of cell over others in the same environment may help doctors
gain more control over autoimmune diseases,” Beeton said.
“The majority of current
treatments are general, broad-spectrum immunosuppressants,” said Redwan
Huq, lead author of the study and a graduate student in the Beeton lab.
treatments are general, broad-spectrum immunosuppressants,” said Redwan
Huq, lead author of the study and a graduate student in the Beeton lab.
“They’re going to affect all
of these cells, but patients are exposed to side effects from infections to
increased chances of developing cancer. So we get excited when we see something
new that could potentially enable selectivity,” Huq said.
of these cells, but patients are exposed to side effects from infections to
increased chances of developing cancer. So we get excited when we see something
new that could potentially enable selectivity,” Huq said.
Since the macrophages and other
splenic immune cells are unaffected, most of a patient’s existing immune system
remains intact, he said. The soluble nanoparticles synthesised at Rice
University in the US have shown no signs of acute toxicity in prior rodent
studies, he said.
splenic immune cells are unaffected, most of a patient’s existing immune system
remains intact, he said. The soluble nanoparticles synthesised at Rice
University in the US have shown no signs of acute toxicity in prior rodent
studies, he said.
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to and for those affected by Multiple Sclerosis
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