Published on: October 4, 2023
Our understanding of the biology of multiple sclerosis is changing. New research sheds light on a potential hidden reason why disability continues to worsen for many patients, despite available therapies.
Since the first case of MS was identified 150 years ago, researchers have methodically sought to advance the understanding of this complex disease. 4 In the last 20 years, scientific discovery has led to a greater understanding of this neurological disease and the development of dozens of disease-modifying therapies. So why then, does the disease continue to progress?
Is there something more?
A new paradigm is emerging
It has long been thought that MS goes into periods of remission – times when the disease is not active or causing damage.
But new science is challenging that belief.
A look inside the brain
Deep within the brain of those living with MS, researchers have discovered that there is a ‘smoldering process’ underway. Some areas of MS in the brain remain continually active causing destruction – even in times of remission – when there are no relapses.5,6,7 Similar to slow-burning embers, this smoldering process within the brain is thought to drive disability regardless of where a patient is on the spectrum of disease – RRMS, PPMS, PRMS, and SPMS. 5 This emerging science represents an overlooked hidden driver of disability.
Many current therapies work in the areas outside the brain, and for many people with MS these can have little to no impact on the smoldering process inside the brain that may be driving disease disability.5 The smoldering process in MS is emerging as the disease underneath the disease.
Evidence shows that the smoldering process starts early on and continues its destructive work, leading to more and more disability. 5,6 If science can target disability at its source—halting the smoldering process in the brain—that could potentially change the course of this debilitating disease forever.
An endless pursuit for answers
For nearly 20 years, Sanofi has been deeply committed to delivering innovative solutions to address the needs of people living with MS. The big challenge now is finding ways to halt disability.
We are leveraging our deep expertise in neurology to break new ground in the study of MS. Our research teams are seeking ways to control the smoldering process within the brain to ultimately halt disability progression and give people with MS hope for a brighter future.
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