In the largest MS genetics study ever undertaken, a global collaboration of scientists has identified 29 new genetic variants associated with MS, and confirmed 23 others previously associated with the disease, verifying a major role for the immune system in the development of MS. The study involved nearly 10,000 people with MS and more than 17,000 controls without MS, and was funded by the Wellcome Trust, the National Institutes of Health, the National MS Society and many other organizations. Some 250 investigators of the International MS Genetics Consortium and the Wellcome Trust Case Control Consortium 2 participated in the study, published in the August 11, 2011 issue of Nature (2011;476[7359]:214-219). The results are now to be confirmed and expanded in an independent, second large-scale set of cases with a research grant from the National MS Society.
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