October 17, 2010 /
This report is part of a 12-month Clinical Context series.
By Richard Robinson, Contributing Writer, MedPage Today Published: October 16, 2010 Reviewed by Michael J. Olek, DO; Director, Newport Doctors Multiple Sclerosis Clinic. |
GOTHENBURG, Sweden — Adjunctive simvastatin provided no benefit in multiple sclerosis patients taking intramuscular interferon beta-1a (Avonex), results of a new study showed.
“The study gave a clear result that simvastatin cannot be recommended as an add-on therapy for intramuscular interferon beta-1A,” according to Per Soelberg Sorensen, MD, of Copenhagen University Hospital in Denmark.
But while simvastatin offered no additional disease control compared with placebo, it was safe, Soelberg Sorensen said at the European Committee for Treatment and Research in Multiple Sclerosis meeting.
“We know that statins have immunomodulatory properties” he said, and in a small open trial, simvastatin reduced gadolinium-enhancing lesions in MS.
However, a small trial of atorvastatin as combination therapy in MS indicated it might reduce the effect of subcutaneous interferon beta-1a.
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